Work in Dr. Ghosh’s lab focuses on biologically-inspired, rational design of biomolecules (i.e. peptides and proteins) and nanoscale materials for therapeutics in cancer and mucosal-associated diseases.
One area of emphasis is the use of combinatorial libraries to identify peptides that achieve transport through biological barriers, including the blood-brain barrier, mucus, and in solid tumors.
From this information, design criteria can be developed towards the design of drug carriers that achieve improved, therapeutic delivery.
Another long-term goal of the lab is to exploit the biology of diseases to develop biological nanoparticles that achieve successful delivery of therapeutic agents.