August 7, 2024
Division Head and Professor of Pharmacology & Toxicology and Doluisio Regents Professor Karen Vasquez, Ph.D. recently published an article in Nature Communications. The study, titled “Obesity increases genomic instability at DNA repeat-mediated endogenous mutation hotspots,” represents the first demonstration that obesity increases genetic instability at alternative DNA structures (in this case H-DNA), which are hotspots for mutations in human cancers.