Generic and chemical class therapeutic substitution are changing the delivery of medicines. If different products are therapeutically equivalent it makes sense to allow the use of the cheaper alternative. Thus, the Food and Drug Administration as well as the pharmaceutical industry are extremely interested in answering the question of whether switching a patient from one drug product to another will result in the same therapeutic efficacy and safety profile. The primary mission of our laboratories is to apply the principles of biopharmaceutics, pharmacokinetics, and drug metabolism to evaluate and design drug delivery systems to ensure the safety and efficacy of drug products. This involves the development of sensitive and selective analytical methodology to quantitatively measure the concentration of drugs in biological systems and to better understand the relationship between drug solubility and drug permeability through biological membranes. We have initiated research in the pharmacokinetic evaluation and delivery of oligonucleotides. Graduate students and research assistants acquire knowledge in the areas of physical and analytical chemistry, statistics, data processing, computer assisted pharmacokinetics and in the experimental design of clinical protocols. Grants and contracts from the government and the pharmaceutical industry provide our state-of-the-art laboratory equipment.
Dr. Salomon Stavchansky, professor of pharmaceutics, is one of four named to the Hall of Distinguished Alumni at the University of Kentucky’s College of Pharmacy.
Stavchansky, who received his Ph.D. in pharmaceutical sciences from the UK College of Pharmacy in 1974, has directed and participated in research concerning the development of analytical methodology for the measurement of drugs in biological fluids; the absorption, metabolism, distribution, and elimination of drugs from biological fluids in animals and man; and the evaluation and design of drug delivery systems. His pioneering work has resulted in more than 150 publications, 270 national and international presentations, and two book chapters.
The honor recognizes accomplishments of UK graduates who have left an indelible mark on health care, industry and academia. The awards’ presentation was conducted in late March.