The Molecular Pharmaceutics & Drug Delivery Seminar Series Presents:
Dr. Chen Mao, Distinguished Scientist, Genentech
Computation simulation of disintegration and dissolution or solid-oral dosage form
Tuesday, February 27, 2024
11:00 a.m. – 12:00 p.m.
PHR 4.114
In-Person/Hybrid
Dr. Chen Mao is a Principal Scientist in the Small Molecule Pharmaceutics group at Genentech, Inc. He received his Ph.D. in Industrial and Physical Pharmacy from Purdue University. Prior to joining Genentech, he assumed various scientist positions at XenoPort and Schering-Plough. Dr. Mao co-chairs the Materials Science and Predictive Modeling Working Group of the IQ Consortium. He is an Adjunct Assistant Professor in the College of Pharmacy at the University of Texas at Austin. He also serves in the editorial board of Drug Development and Industrial Pharmacy and the scientific advisory board of Journal of Pharmaceutical Sciences.
The primary focus of my group is solid dosage formulation development and manufacturing for small molecule pharmaceutical compounds. A main research focus is to investigate the behaviors of pharmaceutical powders involved in drug product manufacturing, such as powder flow, compaction, mixing, and segregation. We study these powder behaviors through a combination of experimental and computational approaches and develop predictive tools toward commercial-scale drug product manufacturing. We are also interested in applying predictive modeling to fundamental processes involved in the solid dosage form performance, such as dissolution, disintegration, or relaxation. We emphasize the employment of mathematical tools, such as finite difference method or finite element method, to develop models leading to in-depth understanding and prediction of pharmaceutically relevant processes at the mechanistic or phenomenological levels.