Progression through the drug development process ranges from characterization of the lead compound to in vivo efficacy studies. At TherapeUTex, our goal is to aid and guide the development of drug products and technologies through this development process by providing services including drug formulation and delivery, in vitro and in vivo preclinical and proof-of-concept studies, lab-scale formulation, stability studies, and production. State-of-the-art analytical technologies and facilities at TherapeUTex provide the necessary tools to deliver the trustworthy results our customers expect. Our scientists, together with collaborating scientists from academia and industry, provide broad expertise in the pharmaceutical and biotech fields, with the flexibility to customize projects tailored to our clients’ needs.
I invite you to visit our Services and Capabilities section below, and to contact us with your research needs.
Esther Maier, Ph.D., TherapeUTex Lead
Services and Capabilities
Preclinical Service Center
The goal of the TherapeUTex Preclinical Core Lab is to characterize properties of new therapeutic compounds in animal models by focusing on drug delivery and pharmacokinetic/pharmacodynamic (PK/PD) studies.
Efforts include drug formulation and optimization of delivery method as well as development of various disease-related animal models with expertise in infectious disease and cancer/angiogenesis, evaluation of optimal drug concentrations, toxicity, efficacy, and target validation by tissue analysis of drug accumulation, metabolism, and elimination.
Formulation Characterization
- Lab-scale Formulation Production
- Method Development
- Forced Degradation
- Assay and Related Substances
- ICH Stability Testing
- Dissolution / Drug Release Testing
- USP paddles/baskets/small volume
- Franz/Immersion cells
- Chemical Analysis
- Liquid Chromatography-Triple Quadrupole Mass Spectrometry
- Liquid Chromatography-UV/PDA
- Thermal Gravimetric Analysis
- Differential Scanning Calorimetry
- Physical Analysis
- Texture analysis
- Viscometry / Rheometry
- Microscopy/Spectroscopy
- Scanning Electron Microscopy
- X-Ray Powder Diffraction
- Light/BF/Fluorescence Microscopy
- Particle Size/Aerosol Characterization
- Geometric Particle Size Distribution
- Micron, submicron scales
- Wet/dry dispersion
- Zetapotential
- Aerodynamic Particle Size
- Next Generation Impactor
- Geometric Particle Size Distribution
In Vitro and In Vivo Modeling
- Preclinical Development
- Dose ranging
- Preclinical formulation development
- MTD, Toxicology
- PK/PD
- Efficacy
- Biodistribution
- In vivo rodent models/services
- Orthotopic and syngeneic tumors
- Anti-cancer vaccines
- Bleomycin-induced Pulmonary Fibrosis
- Obesity
- Rodent vivarium with general husbandry
- Surgery and blood collection
- Imaging (MRI, IVIS)
- Rodent Drug Delivery
- Intravenous (tail vein, jugular)
- Subcutaneous
- Intraperitoneal
- Intramuscular
- Oral gavage
- Intratracheal dosing (non-invasive)
- Nose-only pulmonary dosing
- In vitro models/services
- Cell culture
- Aerosol testing