Pharmacology & Toxicology

In a recent article in the Proceedings of the National Academy of Sciences (PNAS), ongoing research into the causes of manganese-induced parkinsonism has revealed a possible treatment option. Dr. Somshuvra Mukhopadhyay and a team of researchers have released new findings that the PHD2 inhibitor, which is the cell’s master oxygen sensor, has a second physiologically essential function – to also act as the cell’s manganese sensor.