Translational Research in Drug Delivery

This collaborative research area is focused on bridging basic science and clinical therapeutics leading to the discovery of new drug delivery systems that can be brought to market.

Group Leader

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Faculty Participants: College of Pharmacy

Croyle, Maria A., Ph.D.

Work in Dr. Croyle’s lab focuses on the development of novel methods for rapid immunization against dangerous pathogens like Ebola. Additional projects focus on the long-term physiological effects of virus infection with respect to the immune response and drug metabolism.

Cui, Zhengrong, Ph.D.

Research focuses on rational drug and vaccine delivery including nanoparticles for vaccine and anti-cancer drug delivery, non-invasive immunization onto the skin, and cancer chemo-immunotherapy.

Ghosh, Debadyuti (Rana), Ph.D.

Work in Dr. Smyth’s lab focuses on the development of novel methods for drug delivery including inhalation, nasal, transdermal, ophthalmic, and oral delivery systems for a variety of diseases. Translation of these technologies to the clinic is the long-term goal of the lab and is supported by developing a mechanistic understanding of the complex physical and biological systems.

Kuhn, John G., Pharm.D.

Dr. Kuhn’s research is concentrated on deriving information related to the clinical pharmacology of anticancer agents.

Maniruzzaman, Mohammed, Ph.D., SRPharmS, MAS

Work in Dr. Maniruzzaman’s lab focuses on pharmaceutical process engineering, continuous manufacturing and 3D printing of medicines. Additional projects focus on 3D bioprinting of scaffolds and smart medical implants as well as ultra-portable drug delivery devices.

Smyth, Hugh D., Ph.D.

Work in Dr. Smyth’s lab focuses on the development of novel methods for drug delivery including inhalation, nasal, transdermal, ophthalmic, and oral delivery systems for a variety of diseases. Translation of these technologies to the clinic is the long-term goal of the lab and is supported by developing a mechanistic understanding of the complex physical and biological systems.

Stavchansky, Salomon A., Ph.D.

The primary mission of Stavchansky’s laboratories is to apply the principles of biopharmaceutics, pharmacokinetics, and drug metabolism to evaluate and design drug delivery systems to ensure the safety and efficacy of drug products.

Zhang, Feng, Ph.D.

Research focuses on designing novel manufacturing processes and formulation compositions to prepare amorphous dispersions of BCS classes II and IV compounds in order to improve these compounds’ pharmacokinetic performance.

Associated Institute

Faculty Participants: College of Engineering, Department of Biomedical Engineering

Peppas, Nicholas A., Sc.D.

Work in Dr Peppas’ laboratory focuses on the use of intelligent biopolymers for drug and protein delivery under conditions of external physiological triggering mechanisms. In addition, his group is developing novel transmucosal and oral delivery systems for insulin, interferon-beta and calcitonin and is studying the potential of developing novel transmucosal systems for siRNA delivery.